Global Vaccine Safety

Other AEFI related topics

Vaccine safety alerts

Careful investigation of all serious AEFIs is critical. The ultimate goal of an investigation is to determine the likelihood of a causal link between a reported AEFI and the vaccine(s) administered or the vaccination process, or alternately to find another cause. The findings of the investigation should lead to appropriate action, where needed, to prevent further AEFIs. Effective and efficient management of AEFIs is an essential component of all immunization programmes in order to ensure continued public confidence in vaccination, and ultimately to ensure high immunization coverage and thereby reduction in disease and death due to vaccine-preventable diseases.

WHO, at the request of governments of Member States, provides assistance to national authorities for the investigation of serious AEFIs. In particular, WHO works with national authorities to ensure appropriate investigation and response to serious AEFIs reported following the administration of WHO-prequalified vaccines.

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