Human African trypanosomiasis

The Drugs for Neglected Diseases initiative – DNDi

The Drugs for Neglected Diseases initiative (DNDi) has been established in 2003 by seven organizations – the Oswaldo Cruz Foundation from Brazil, the Indian Council for Medical Research, the Kenya Medical Research Institute, the Ministry of Health of Malaysia and France’s Pasteur Institute; one humanitarian organization, Médecins sans Frontières (MSF); and one international research organization, the UNDP/World Bank/WHO’s Special Programme for Research and Training in Tropical Diseases (TDR) – to promote collaboration both among developing countries and between developing and developed countries. DNDi doesn’t conduct research or scientific work itself to develop drugs; instead, it capitalizes on existing, fragmented R&D capacity and complements it with additional expertise as needed. This “virtual” approach is meant to help cut research costs.

DNDi works in the research for better use of existing medicines (NECT), to rediscover compounds (Fexinidazole and other nitroimidazoles) and identifying new compounds (i.e. oxaboroles).