Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Humans are infected via the bite of phlebotomine sandflies, which breed in forest areas, caves and adobe brick houses where most of the transmission to humans takes place.
There are four main types of the disease:
- In cutaneous forms, skin ulcers usually form on exposed areas, such as the face, arms and legs. These usually heal within a few months, leaving scars.
- Diffuse cutaneous leishmaniasis produces disseminated and chronic skin lesions resembling those of lepromatous leprosy. It is difficult to treat.
- In mucocutaneous forms, the lesions can partially or totally destroy the mucous membranes of the nose, mouth and throat cavities and surrounding tissues.
- Visceral leishmaniasis, also known as kala azar, is characterized by high fever, substantial weight loss, swelling of the spleen and liver, and anaemia. If left untreated, the disease can have a fatality rate as high as 100% within two years.
TDR related research
TDR supports research on this disease. Our work is being conducted in the following areas:
Single dose treatment for visceral leishmaniasis can be effectively given in rural public hospitals
Standards for cutaneous leishmaniasis clinical trials published