Tuberculosis (TB)

Guidelines for surveillance of drug resistance in tuberculosis

WHO/HTM/TB/2009.422

Guidelines for surveillance of drug resistance in tuberculosis - 4th edition

This fourth edition of the WHO Guidelines for surveillance of drug resistance in tuberculosis presents up-to-date guidance on the design and implementation of setting-specific surveys and surveillance systems to measure the burden and trends of drug-resistant tuberculosis. The guidelines address recent advancements in drug susceptibility testing, including testing for second-line drugs and the use of rapid diagnostics. The document also presents strengthened guidance on data management and analysis, ethical considerations in surveys and surveillance of drug resistance, and investigation of associations between anti-tuberculosis drug resistance and HIV-infection and other risk factors.

Supplementary materials to the guidelines:

Script for use in analysis of data: This script in Stata (http://www.statacorp.com) analyzes a sample cluster survey dataset using methods for multiple imputation of missing data and logistic regression with robust errors, to account for sampling design effects. (Please download the files below by right clicking and then select save as.)

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