Mental health

Treatment of psychostimulant dependence

Question 3: Are pharmacotherapies safe and effective for the treatment of psychostimulant dependence (maintenance or relapse prevention) in non-specialized settings?

Management of substance abuse

  • Population: stimulant dependence (amphetamines, methamphetamines and cocaine)
  • Interventions:
    • naltrexone
    • dexamphetamine
  • Comparison: placebo or treatment as usual
  • Outcomes:
    • stimulant use
    • psychosocial outcomes
    • adverse effects.


Dexamphetamine should not be offered for the treatment of stimulant use disorders in non-specialized settings.
Strength of recommendation: STRONG

Evidence profile