Mental health

Role of anticholinergic medications in patients requiring long-term antipsychotic treatment for psychotic disorders

[2012]

Recommendation(s)

Anticholinergics should not be used routinely for preventing extrapyramidal side-effects in individuals with psychotic disorders (including schizophrenia) treated with antipsychotics.
Strength of recommendation: STRONG
Quality of evidence: VERY LOW

Short-term use of anticholinergics may be considered only in individuals with significant extrapyramidal side-effects when dose reduction and switching strategies have proven ineffective, or when these side-effects are acute or severe.
Strength of recommendation: STANDARD
Quality of the evidence: VERY LOW

Anticholinergics should not be prescribed to pregnant women for the extrapyramidal side-effects of antipsychotic drugs except for acute short-term use.
Strength of recommendation: STRONG
Quality of evidence: VERY LOW

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