Mental health

Anti-depressants or benzodiazepines in patients with complaints of depressive symptoms (in absence of depressive episode/disorder)

Question 2: In patients with complaints of depressive symptoms (in absence of current/prior depressive episode/disorder), are anti-depressants or benzodiazepines better (more effective in symptom reduction in the short-term [immediate] or long-term [>6 months]) and as safe as usual care?

  • Population: patients with minor or subsyndromal depression (complaints of depressive symptoms in absence of depressive episode)
  • Interventions: antidepressants or benzodiazepines
  • Comparison: placebo
  • Outcomes:
    • symptom reduction
    • adverse events.

Recommendation(s)

Neither antidepressants nor benzodiazepines should be used for the initial treatment of individuals with complaints of depressive symptoms in absence of current/prior depressive episode/disorder.
Strength of recommendation: STRONG

Evidence profile

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