Mental health

Physical activity

Question 6: Is advice on physical activity better (more effective than/as safe as) than treatment as usual in adults with depressive episode/disorder with inactive lifestyles?

  • Population: adults with depressive episode/disorder
  • Interventions: advice on physical activity
  • Comparison: treatment as usual
  • Outcomes:
    • symptom severity post intervention
    • functioning post intervention
    • symptom severity at 6 to 12 months follow-up
    • adverse effects (including tolerability).


Advice on physical activity should be encouraged as part of treatment for adults with depressive episode/disorder with inactive lifestyles. In moderate and severe depression, this intervention should be considered as adjunct to antidepressants or brief structured psychological treatments.
Strength of recommendation: STANDARD

Evidence profile