Mental health

Antidepressants (Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors) in treatment of adults with depression

[2012]

Recommendation(s)

Antidepressants should not be considered for the initial treatment of adults with mild depressive episode.
Strength of recommendation: CONDITIONAL
Quality of evidence: LOW

Tricyclic Antidepressants or fluoxetine should be considered in adults with moderate to severe depressive episode/disorder.
Strength of recommendation: CONDITIONAL
Quality of evidence: LOW

If drug treatment is required in older people, tricyclic antidepressants should be avoided if possible.
Strength of recommendation: CONDITIONAL
Quality of evidence: LOW

If drug treatment is required in women with depressive episode who are planning a pregnancy or pregnant or breastfeeding, tricyclic antidepressants or fluoxetine should be considered.
Strength of recommendation: CONDITIONAL
Quality of evidence: LOW

Evidence profile

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