Mental health

Pharmacological interventions (antidepressants) for people with dementia who have associated depression



In people with dementia and severe depression, or when psychosocial interventions prove ineffective, the use of selective serotonin reuptake inhibitors (SSRIs) (but not tricyclic antidepressants [TCAs]) may be considered.

In people with dementia and mild to moderate depression, antidepressants should not be offered as a first-line treatment.

Strength of recommendation: CONDITIONAL
Quality of evidence: LOW