Antidepressants (Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors) in adolescents with depressive episode/disorder
Question 11: Are antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRI)) effective and safe in adolescents with depressive episode/disorder?
- Population: adolescents with depressive episode/disorder
- Interventions: antidepressant drugs:
- tricyclics and related
- selective serotonin reuptake inhibitors
- Comparison: placebo
- reduction of symptoms
- improvement in functioning
- acceptability profile
- adverse effects of treatment (including suicide ideas/ behaviour for SSRIs
Fluoxetine, but not Tricyclic antidepressants (TCA) or other Selective serotonin reuptake inhibitors (SSRI), may be considered as one possible treatment of adolescents with depressive episode in non-specialist settings. Adolescents on fluoxetine should be monitored closely for suicide ideas/behaviour. For all adolescents on fluoxetine, support and supervision from a mental health specialist should be obtained, if available.
Strength of recommendation: STANDARD