Mental health

Antidepressants (Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors) in children 6-12 years of age with depressive episode/disorder

Question 10: Are antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRI)) effective and safe in children 6-12 years of age with depressive episode/disorder?

Management of child and adolescent mental disorders

  • Population: children (6-12 years) with depressive episode/disorder
  • Interventions: antidepressant drugs:
    • tricyclics and related
    • selective serotonin reuptake inhibitors
  • Comparison: placebo
  • Outcomes:
    • symptom reduction
    • overall performance at school
    • family functioning
    • adverse effects of treatment
    • improvement in physical health
    • user and family satisfaction
    • reduction in risk behaviour.

Recommendation(s)

Antidepressants (Tricyclic antidepressants (TCA), Selective serotonin reuptake inhibitors (SSRI)) should not be used for the treatment of children 6-12 years of age with depressive episode/disorder in non-specialist settings.
Strength of recommendation: STRONG

Evidence profile

Share