- Every year there are 20 million hepatitis E infections, over three million acute cases of hepatitis E, and 70 000 hepatitis E-related deaths.
- Hepatitis E is usually self-limiting but may develop into fulminant hepatitis (acute liver failure).
- The hepatitis E virus is transmitted via the faecal-oral route, principally via contaminated water.
- Hepatitis E is found worldwide, but the prevalence is highest in East and South Asia.
- China has produced and licensed the first vaccine to prevent hepatitis E virus infection, although it is not yet available globally.
Hepatitis E is a liver disease caused by the hepatitis E virus: a non-enveloped, positive-sense, single-stranded RNA virus.
The hepatitis E virus is transmitted mainly through contaminated drinking water. It is usually a self-limiting infection and resolves within 4–6 weeks. Occasionally, a fulminant form of hepatitis develops (acute liver failure), which can lead to death.
Globally, there are approximately 20 million incident hepatitis E infections every year.
Hepatitis E is found worldwide and different genotypes of the hepatitis E virus determine differences in epidemiology. For example, genotype 1 is usually seen in developing countries and causes community level outbreaks while genotype 3 is usually seen in the developed countries and does not cause outbreaks. Globally, 70 000 deaths and 3.4 million cases of acute hepatitis E are attributable to infection with hepatitis E virus genotypes 1 and 2.
The highest seroprevalence rates (number of persons in a population who test positive for the disease) are observed in regions where low standards of sanitation increase the risk for transmission of the virus. Over 60% of all hepatitis E infections and 65% of all hepatitis E deaths occur in East and South Asia, where seroprevalence rates of 25% are common in some age groups. In Egypt, half the population aged above five years is serologically positive for the hepatitis E virus.
The hepatitis E virus is transmitted mainly through the faecal-oral route due to faecal contamination of drinking water. Other transmission routes have been identified, which include:
- foodborne transmission from ingestion of products derived from infected animals;
- zoonotic transmission from animals to humans;
- transfusion of infected blood products;
- vertical transmission from a pregnant woman to her fetus.
Although humans are considered the natural host for the hepatitis E virus, antibodies to the hepatitis E virus or closely related viruses have been detected in primates and several other animal species.
Hepatitis E is a waterborne disease, and contaminated water or food supplies have been implicated in major outbreaks. The ingestion of raw or uncooked shellfish has also been identified as the source of sporadic cases in endemic areas.
The risk factors for hepatitis E are related to poor sanitation in large areas of the world and shedding of the hepatitis E virus in faeces.
The incubation period following exposure to the hepatitis E virus ranges from three to eight weeks, with a mean of 40 days. The period of communicability is unknown.
The hepatitis E virus causes acute sporadic and epidemic viral hepatitis. Symptomatic infection is most common in young adults aged 15–40 years. Although infection is frequent in children, the disease is mostly asymptomatic or causes a very mild illness without jaundice (anicteric) that goes undiagnosed.
Typical signs and symptoms of hepatitis include:
- jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools);
- anorexia (loss of appetite);
- an enlarged, tender liver (hepatomegaly);
- abdominal pain and tenderness;
- nausea and vomiting;
These symptoms are largely indistinguishable from those experienced during any acute phase of hepatic illness and typically last for one to two weeks.
In rare cases, acute hepatitis E can result in fulminant hepatitis (acute liver failure) and death. Overall population mortality rates from hepatitis E range from 0.5% to 4.0%. Fulminant hepatitis occurs more frequently during pregnancy. Pregnant women are at greater risk of obstetrical complications and mortality from hepatitis E, which can induce a mortality rate of 20% among pregnant women in their third trimester.
Cases of chronic hepatitis E infection have been reported in immunosuppressed people. Reactivation of hepatitis E infection has also been reported in immunocompromised people.
Cases of hepatitis E are not clinically distinguishable from other types of acute viral hepatitis. Diagnosis of hepatitis E infection is therefore usually based on the detection of specific antibodies to the virus in the blood.
Two additional diagnostic tests require specialized laboratory facilities and are used only in research studies. These are:
- reverse transcriptase polymerase chain reaction (RT-PCR) to detect the hepatitis E virus RNA;
- immune electron microscopy to detect the hepatitis E virus.
Hepatitis E should be suspected in outbreaks of waterborne hepatitis occurring in developing countries, especially if the disease is more severe in pregnant women, or if hepatitis A has been excluded.
There is no available treatment capable of altering the course of acute hepatitis. Prevention is the most effective approach against the disease.
As hepatitis E is usually self-limiting, hospitalization is generally not required. However, hospitalization is required for people with fulminant hepatitis and should also be considered for infected pregnant women.
The risk of infection and transmission can be reduced by:
- maintaining quality standards for public water supplies ;
- establishing proper disposal systems to eliminate sanitary waste.
On an individual level, infection risk can be reduced by:
- maintaining hygienic practices such as hand washing with safe water, particularly before handling food;
- avoiding drinking water and/or ice of unknown purity;
- avoiding eating uncooked shellfish, and uncooked fruits or vegetables that are not peeled or that are prepared by people living in or travelling in highly endemic countries.
In 2011, the first vaccine to prevent hepatitis E infection was registered in China. Although it is not available globally, it could potentially become available in a number of other countries.
Guidelines for epidemic measures
In epidemics, WHO recommends:
- determining the mode of transmission;
- identifying the population specifically exposed to increased risk of infection;
- eliminating a common source of infection;
- improving sanitary and hygienic practices to eliminate faecal contamination of food and water.
WHO is working in the following areas to prevent and control viral hepatitis:
- raising awareness, promoting partnerships and mobilizing resources;
- evidence-based policy and data for action;
- prevention of transmission; and
- screening, care and treatment.
WHO also organizes World Hepatitis Day on 28 July every year to increase awareness and understanding of viral hepatitis.