Maternal, newborn, child and adolescent health

Ethambutol efficacy and toxicity

Literature review and recommendations for daily and intermittent dosage in children

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Authors:
Donald, Peter; Maher, Dermot; Maritz, Stephan; Qazi, Shamin Ahmad; World Health Organization

Publication details

Number of pages: 69
Publication date: 2006
Languages: English
WHO reference number: WHO/HTM/TB/2006.365; WHO/FCH/CAH/2006.3

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Overview

This review was produced by the Stop TB Department and the Department of Child and Adolescent Health and Development of the World Health Organization. This literature was prompted by the varying recommendations in the literature, including WHO publications, with regard to the dose of ethambutol for the treatment of tuberculosis (TB) in children.This document reviews the published evidence relating to the dosage, toxicity and pharmacokinetics of Ethambutol (EMB) in children and adults and makes a recommendation for the dosage of EMB to be used in childhood that represents the best compromise between efficacy and toxicity.