Malaria

Report of the Technical Expert Group (TEG) on intermittent preventive therapy in infancy (IPTi)

October 2007

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Authors:
World Health Organization

Publication details

Number of pages: 12
Publication date: 2007
Languages: English

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Overview

On 8-10 October 2007, the WHO Technical Expert Group reviewed the evidence available on the use of sulfadoxine-pyrimethamine (SP) as IPTi. This was based on data from six published or in-press randomised, placebo-controlled, clinical trials conducted in eastern, southern and western areas of Africa, with relatively high malaria endemicity (estimated Entomological Inoculation Rate ≥ 29), which enrolled over 4000 children in the SP intervention arms. In addition, considerable evidence was provided as unpublished reports from the IPTi consortium on the pooled analysis of data from these six studies on protective efficacy and safety of SP-IPTi.