Report of the technical consultation on intermittent preventive treatment in infants (IPTi)
In October 2006 and October 2007, WHO convened meetings of the Technical Expert Group (TEG) on Intermittent Preventive Treatment in Infants to review the available evidence on the safety, efficacy and other relevant aspects of IPTi with sulfadoxine-pyrimethamine (SPIPTi) delivered through the Expanded Programme for Immunization (EPI). At the time six randomised, placebo-controlled, clinical trials with SP-IPTi were being, or had been conducted in areas of Africa south of the Sahara with relatively high malaria endemicity.
TEG 2006 concluded that SP-IPTi held promise as a potential malaria control intervention, noting that three of the studies were yet ongoing or unpublished. At the TEG 2007, at which time the six studies had been completed, the committee concluded that, though IPTi remains a potential intervention for malaria control, the use of SP-IPTi cannot be recommended as a strategy for general deployment based on the assessment of the risks and benefits, and advised a future review of further evidence when available.