Drug resistance and response

Efficacious antimalarial medicines are critical to malaria control. Continuous monitoring of their efficacy is needed to inform treatment policies in malaria-endemic countries, and to ensure early detection of, and response to, drug resistance. The emergence of P. falciparum resistance to artemisinin is an urgent public health concern, threatening the sustainability of the ongoing global effort to reduce the burden of malaria. The Global Technical Strategy for Malaria 2016–2030 calls on countries and global malaria partners to monitor the efficacy of antimalarial medicines so that the most appropriate combinations can be selected for national treatment policies.

Antimalarial drug efficacy

Efficacious antimalarials are critical to malaria control, and continuous efficacy monitoring is needed to inform treatment policies and to ensure early detection of drug resistance.

Antimalarial drug resistance

To date, parasite resistance has been documented in three of the five malaria species known to affect humans: P. falciparum, P. vivax and P. malariae.

Tools for monitoring antimalarial drug efficacy

Routine monitoring of antimalarial drug efficacy is necessary for effective case management and early detection of resistance.

Global database and maps

The global database on antimalarial drug efficacy and resistance centralizes data on the status of drug efficacy and drug resistance in malaria endemic countries.

Containment of artemisinin resistance

Containment activities are ongoing in all affected countries in the Greater Mekong Subregion. Urgent action is required to prevent the situation from worsening.

Advisory committees on drug resistance and response

A standing Technical Expert Group (TEG) and 2 time-limited Evidence Review Group (ERG) have been convened to review the latest evidence and provide guidance and recommendations on drug resistance and containment.

Key documents

World Malaria Report 2016

This report contains the latest available data on malaria policies, interventions and trends in all endemic countries.

Contact us

Global Malaria Programme
World Health Organization
20 Avenue Appia
1211 Geneva 27
Tel: +41 22 791 2533
Fax: +41 22 791 4824