Harmonization Project publications

• Harmonization Project Document No. 8: WHO Human Health Risk Assessment Toolkit: Chemical Hazards
  pdf, 3.35Mb

CANCER RISK ASSESSMENT

IPCS Conceptual Framework for Evaluating a Mode of Action for Chemical Carcinogenesis

C. Sonich-Mullin, R. Fielder, J. Wiltse, K. Baetcke, J. Dempsey, P. Fenner-Crisp, D. Grant, M. Hartley, A. Knaap, D. Kroese, I. Mangelsdorf, E. Meek, J. M. Rice, M. Younes, Regulatory Toxicology and Pharmacology Vol. 34, No. 2, October 1, 2001

• IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans
• IPCS Conceptual Framework for Cancer Risk Assessment
  pdf, 73kb
   
• Report of the First Meeting of the Cancer Working Group, 2004, Arlington, Virginia, United States of America
  pdf, 208kb
   
• Conceptual Framework Workshop
  pdf, 58kb
  ref: IPCS Harmonization Workshop - Conceptual Framework for Cancer Risk Assessment, Lyon, France, February 1999
  
• IPCS Scoping Meeting to Address the Human Relevance of Animal Modes of Action in Assessing Cancer Risk
  pdf, 87kb
  Carshalton, United Kingdom, November 2000
  
• Issue Meeting
  pdf, 43kb
  ref: IPCS Workshop on Issues in Cancer Risk Assessment, Hannover, Germany, 1998
• Report of the Bradford Workshop, 2005, Bradford, United Kingdom
  pdf, 288kb

NON-CANCER RISK ASSESSMENT

• IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans
• Report of the Meeting to Extend the IPCS Cancer Framework to Other Endpoints, 2006, WHO Headquarters, Geneva, Switzerland

EXPOSURE ASSESSMENT

• Report of the 1st Meeting of the IPCS Working Group on Uncertainty in Exposure Assessment in Conjunction with a Scoping Discussion on Exposure Data Quality
  pdf, 175kb
• Harmonization Project Document No 3: Principles of Characterizing and Applying Human Exposure Models. WHO (2005)
• Harmonization Project Document No 6: Guidance on Characterizing and Communicating Uncertainty in Exposure Assessment and Guidance on Data Quality in Chemical Exposure Assessment, a two-part publication.
  pdf, 1.61Mb

COMBINED EXPOSURES TO MULTIPLE CHEMICALS

• Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

RISK ASSESSMENT TERMINOLOGY

• Risk Assessment Terminology
  pdf, 973kb
  IPCS Risk Assessment Terminology. Part1: IPCS/OECD Key Generic Terms used in Chemical Hazard/Risk Assessment; Part 2: IPCS Glossary of Key Exposure Assessment Terminology

SKIN SENSITIZATION

• Skin sensitization in chemical risk assessment
  pdf, 488kb
  Harmonization Project Document No.5
• Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment
• Skin sensitization in chemical risk assessment: Summary conclusions and recommendations of the October 2006 workshop
  pdf, 62kb

CHEMICAL-SPECIFIC ADJUSTMENT FACTORS

• Chemical-specifc adjustment factors for Interspecies differences and human variability: Guidance document for use of data in dose/concentration-response assessment
• Final Meeting Record
  pdf, 76kb
  Harmonization Project Meeting to Update the IPCS Document on Chemical-Specific Adjustment Factors, 9-10 December 2004

USE OF PBPK MODELLING

• Harmonization Project Document No.9: Characterization and Application of Physiologically Based Pharmacokinetic models in Risk Assessment
  pdf, 1.67Mb

OTHER

• Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

Web resources

• Devtox web site
  A Web-based resource on developmental toxicology terminology.