New guidance on clinical management of influenza infections (under development)

16 January 2012

WHO is currently developing a standard guideline on clinical management of influenza virus infection. The process includes rigorous evidence review and strictly adheres to the process defined by the Organization for developing its recommendations (Guidelines Review Committee). In order to develop this guidance, WHO considered a wide range of evidence in addition to that of clinical trials.

Topics that are systematically reviewed include effects of influenza antiviral medicines, and vaccination for immunocompromised patients and for health care workers for the protection of patients at higher risk of acute, severe, respiratory disease. The reviewed research outcomes are scored by GRADE approach in order to weigh the recommendations. Furthermore, expected benefits and potential harm when implementing the recommendation accompany each recommendation.