Post-exposure prophylaxis

Post-exposure prophylaxis (PEP) is short-term antiretroviral treatment to reduce the likelihood of HIV infection after potential exposure, either occupationally or through sexual intercourse. Within the health sector, PEP should be provided as part of a comprehensive universal precautions package that reduces staff exposure to infectious hazards at work.

Key publication

Post-exposure prophylaxis to prevent HIV infection

Guidelines created from a Joint WHO/ILO expert consultation on occupational and non-occupational HIV post-exposure prophylaxis held in Geneva in September 2005.


HIV post-exposure prophylaxis for occupational and non-occupational exposure to HIV infection

The use of ARVs for HIV post-exposure prophylaxis (HIV-PEP) following occupational exposure to HIV, and the recent expansion of HIV-PEP to non-occupational situations, have raised numerous areas of uncertainty for policy makers and healthcare providers caring for potentially exposed individuals. Key issues among these are the appropriate indications for HIV-PEP, ART choices, and management strategies to accompany use of PEP for HIV. With the expanding availability of ART in resource-poor settings, issues of provision of HIV-PEP require policy decision that can be implemented in programme and services delivery planning.

Global Health Sector Strategy on HIV/AIDS 2011-2015: Let’s do what’s right for everyone

Global Hepatitis Programme

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HIV/AIDS Department
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