Surveillance of antiretroviral drug toxicity within antiretroviral treatment programmes
This document provides guidance on surveillance of the toxicity of antiretroviral (ARV) drugs. It is intended for national HIV/AIDS programme managers and implementing partners, such as nongovernmental agencies and academic institutions, that are responsible for implementing systems to monitor the safety of ARV drugs. It focuses on approaches that address the particular needs of the HIV/AIDS treatment programmes to monitor the toxicity of ARVs. The proposed approaches include the development and maintenance of targeted spontaneous reporting; active surveillance for specific toxicities within sentinel cohorts; and cohort event monitoring.
The document describes briefly the methods employed, their strengths and limitations, tools available for implementing them and practical issues that would need to be considered for particular settings or countries.