Multiple micronutrient supplementation during pregnancy
Micronutrients are only needed in very small quantities but are essential for normal functioning, growth and development. During pregnancy, micronutrient deficiencies are particularly common due to increased nutrient requirements of the mother and the developing fetus. These deficiencies can negatively impact the health of the mother, her pregnancy, as well as the health of the newborn baby.
The most current evidence shows that giving multiple micronutrient supplements to pregnant women may reduce the risk of low birth weight and of small size for gestational age, compared with iron and folic acid supplementation alone. However, further research is needed to assess the comparative advantage of replacing of iron and folate supplementation with multiple micronutrient supplementation.
WHO documents
Status: guidelines not currently available
Evidence
Cochrane review
Other systematic reviews
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Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression
Kawai K et al.
Bulletin of the World Health Organization, 2011, 89:402–411B, doi:10.2471/BLT.10.083758 -
Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes
Haider BA, Yakoob MY, Bhutta ZA.
BMC Public Health, 2011, 11(Suppl. 3):S19, doi:10.1186/1471-2458-11-S3-S19 -
Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on stillbirths and on early and late neonatal mortality
Ronsmans C et al.
Food and Nutrition Bulletin, 2009, 30(Suppl. 4):S547–S555 -
Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis
Shah PS, Ohlsson A.
Canadian Medical Association Journal, 2009, 180(12):E99–E108, doi:10.1503/cmaj.081777