Marburg virus disease
20 October 2017 - WHO is working to contain an outbreak of Marburg virus disease that has appeared in eastern Uganda on the border with Kenya. The Ministry of Health has sent a rapid response team to the area supported by staff from WHO, the Centers for Disease Control and Prevention (CDC) and the African Field Epidemiology Network (AFNET).
WHO is providing medical supplies, guidance on safe and dignified burials, and has released USD 500 000 from its Contingency Fund for Emergencies to finance immediate response activities.
Marburg virus disease is a severe and highly fatal disease caused by a virus from the same family as the one that causes Ebola virus disease. These viruses are among the most virulent pathogens known to infect humans. Both diseases are rare, but have a capacity to cause dramatic outbreaks with high fatality.
Two large outbreaks that occurred simultaneously in Marburg and Frankfurt in Germany, and in Belgrade, Serbia, in 1967, led to the initial recognition of the Marburg virus disease. Subsequently, outbreaks and sporadic cases have been reported in Angola, Democratic Republic of the Congo, Kenya, South Africa and Uganda.
- 1. antibody enzyme-linked immunosorbent assay (ELISA);
- 2. antigen detection tests;
- 3. serum neutralization tests;
- 4. reverse-transcriptase polymerase chain reaction (RT-PCR) assay; and
- 5. virus isolation by cell culture
Samples collected from patients are an extreme biohazard risk; laboratory testing on non-inactivated samples should be conducted under maximum biological containment conditions. All biological specimens should be packaged using the triple packaging system when transported nationally and internationally.
- Ebola and Marburg virus disease epidemics: preparedness, alert, control, and evaluation
- Personal protective equipment for use in a filovirus disease outbreak (Rapid advice guideline)
- Infection prevention and control guidance for care of patients with suspected or confirmed Filovirus haemorrhagic fever in health-care settings
- Clinical management of patients with viral haemorrhagic fever, a pocket guide for the front-line health workers
- A toolkit for behavioral and social communication in outbreak response
- Field workbook for COMBI planning steps in outbreak response