Buruli ulcer

Provisional guidance on the role of specific antibiotics in the management of Mycobacterium ulcerans disease (Buruli ulcer)

Antibiotics administration and dosages

Usual doses are:

  • rifampicin, 10 mg/kg body weight by mouth daily for 8 weeks;
  • streptomycin, 15 mg/kg body weight by intramuscular injection daily for 8 weeks.

Further details are given in Table I and Annex I.

Table 1: Rifampicin and streptomycin dosage according to patient body weighta

a Adapted from (25).
b Syrup form may be used for children.
c Contraindicated during pregnancy.

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Table of contents

  1. Background
  2. Growing evidence on the role of specific antibiotics
  3. Purpose of this document
  4. Important notes for health workers
  5. Case definitions3
  6. When to suspect M. ulcerans disease
  7. Antibiotics administration and dosages
  8. Treatment
  9. Documenting M. ulcerans disease and monitoring response during and after treatment
  10. Patient information and compliance
  11. Follow-up after antibiotic treatment
  12. Reporting of experiences
  13. Implementation of this guidance
  14. Monitoring
  15. Important issues to consider
  16. Provision of antibiotics
  17. References
  18. Annex 1 - Information on rifampicin, streptomycin and amikacin4
  19. Annex 2 - Treatment cards for inpatient and outpatient use
  20. Annex 3 - Patient register
  21. Annex 4 - Follow-up form after antibiotic treatment
  22. Acknowledgements