Quality of care provided by mid-level health workers: systematic review and meta-analysis
Zohra S Lassi a, Giorgio Cometto b, Luis Huicho c & Zulfiqar A Bhutta a
a. Division of Women and Child Health, Aga Khan University, PO Box 3500, Karachi 74550, Pakistan.
b. Global Health Workforce Alliance Secretariat, World Health Organization, Geneva, Switzerland.
c. Universidad Peruana Cayetano Heredia, Lima, Peru.
Correspondence to Zulfiqar A Bhutta (e-mail: email@example.com).
(Submitted: 10 March 2013 – Revised version received: 28 May 2013 – Accepted: 30 May 2013.)
Bulletin of the World Health Organization 2013;91:824-833I. doi: http://dx.doi.org/10.2471/BLT.13.118786
In 2000, 189 countries adopted the United Nation’s Millennium Declaration and its eight Millennium Development Goals, including Goals 4, 5 and 6, which are directly related to health. However, progress towards achieving the associated health targets falls far below expectations, especially in developing countries. Recent reviews have clearly identified interventions that can have a positive effect on maternal and child health and neonatal survival but implementing them throughout the general population has been hampered by a lack of trained and motivated health workers.1–6 Moreover, the poor performance of health systems in delivering effective, evidence-based interventions for priority health conditions has been linked to the poor retention, inadequate performance and poor motivation of health workers, as well as to shortages of personnel and their maldistribution. As health systems around the world and the international health community increasingly embrace the goal of universal health coverage, which will inevitably result in greater demands on health systems and existing health workers, the need to address these shortcoming is becoming imperative.7 In parallel, there is growing recognition that skilled and semi-skilled mid-level health workers, who are sometimes referred to as “outreach and facility health workers”, can play a major role in community mobilization and in delivering a range of health-care services.
Although mid-level health workers have been defined in a variety of ways (Table 1), the definitions commonly agree that they will have received shorter training than physicians but will perform some of the same tasks.10 Typically, these workers follow certified training courses and receive accreditation for their work.10 Many, such as nurse auxiliaries and medical assistants, undergo shorter training than physicians and the scope of their practice is narrower, but this is not necessarily the case for all. For example, sometimes nurses and nurse practitioners spend more than 5 years in training and perform some of the same tasks as doctors. Similarly, non-physician clinicians may have, in total, spent an equal amount of time in training as medical doctors and may perform a comparable range of tasks, including surgery. Despite differences in the roles and training of mid-level health workers and despite a continuing struggle for their acceptance, today many countries rely ever more heavily on these workers to improve the coverage and equity of health care.11 Although mid-level health workers have played a vital role in many countries’ health-care systems for over 100 years, interest in them has been renewed only in the past 10 years, principally because of the serious shortage of health workers in many developing countries, the burden of diseases such as human immunodeficiency virus (HIV) infection and the emerging importance of other conditions, such as noncommunicable diseases. Many African and Asian countries have successfully invested in these workers.12–15
Our aim was to test the hypothesis that mid-level health workers are as effective as higher level health workers at providing good quality care in priority areas of the health service. We also hoped to increase understanding of their effectiveness and of how they can best be integrated into national health-care systems.
We performed a systematic review of studies on the role of mid-level health workers in delivering to the general population health-care services that are associated with the achievement of Millennium Development Goals on health and nutrition or with the management of noncommunicable diseases. We included all randomized and nonrandomized controlled trials, controlled before-and-after trials and interrupted time-series studies. Less rigorously designed studies, such as observational (cohort and case–control) and descriptive studies, were also examined to understand the context within which mid-level health worker programmes are implemented, the types of health-care providers involved, the types of interventions delivered and the outcomes obtained. We aimed to compare the effectiveness of: (i) different kinds of mid-level health workers; (ii) mid-level health workers and doctors or community health workers; and (iii) mid-level health workers working alone or in a team.
For the purpose of this study, a mid-level health worker was defined as a health-care provider who is not a medical doctor or physician but who provides clinical care in the community or at a primary care facility or hospital. He or she may be authorized and regulated to work autonomously, to diagnose, manage and treat illness, disease and impairments, or to engage in preventive care and health promotion at the primary- or secondary-health-care level. The definition includes midwives, nurses, auxiliary nurses, nurse assistants, non-physician clinicians and surgical technicians (Table 2). Workers who specialize in health administration or who perform only administrative tasks and those who provide rehabilitative or dentistry services were excluded. However, no type of patients or recipient of health services was excluded.
A systematic search of the Cochrane Library, Medline, Embase and Cinahl databases, the Latin America and the Caribbean database LILACS and the Social Sciences Citation Index was performed, without language restrictions. Articles in both peer-reviewed and grey literature were included and the authors of relevant papers were contacted to help identify additional published or unpublished works.
The main health-care outcomes we considered were morbidity, mortality, outcomes associated with care delivery, health status, quality of life, service utilization and the patient’s satisfaction with care. Two review authors independently extracted all outcome information. Data were collected on all health workers and care recipients involved, on health-care settings and on each study’s design and outcomes.
The statistical analysis was performed using Review Manager (Nordic Cochrane Centre, Copenhagen, Denmark). Risk ratios (RRs) and mean differences, with 95% confidence intervals (CIs), were calculated for dichotomous and continuous variables, respectively. Study heterogeneity was assessed using I2 and χ2 statistics. Two review authors independently assessed the risk of bias in each study using a form describing standard criteria, which was obtained from the Cochrane Effective Practice and Organisation of Care Group.18 We analysed the quality of the evidence supporting study findings using the approach developed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group.19,20 The quality of the evidence for each outcome was rated high, moderate, low or very low.
The search identified 24 246 database records, which led to the retrieval of documentation on 327 studies for a full text review (Fig. 1). Of the 327, 53 met the eligibility criteria and were included in the review (Table 3, available at: http://www.who.int/bulletin/volumes/91/11/13-118786). Most studies compared either care provided by midwives with that provided by doctors working in a team along with midwives or care provided by nurses with that provided by doctors. Moreover, most were conducted in high-income countries and at tertiary care facilities. The studies were experimental in design and their results were pooled for the meta-analysis (Table 4). Since the evidence in all studies was found to be of low or very low quality, as assessed using GRADE criteria, the findings of the meta-analysis should be interpreted with caution.
Fig. 1. Database search for experimental studies of mid-level health workers’ effectiveness, 1973–2012
Table 3. Experimental studies included in meta-analysis of mid-level health workers’ effectiveness, 1973–2012
Table 4. Meta-analysis of the effectiveness of mid-level health workers, 1973–2012
Thirteen of the 53 studies21–33 compared the care provided by midwives with that provided by doctors working in a team with midwives. On meta-analysis, no significant difference in the antenatal hospitalization rate was found between care provided by midwives alone and that provided by doctors working with midwives (RR: 0.95; 95% CI: 0.79–1.13). However, the absence of intrapartum analgesia was more likely with care from midwives alone (RR: 1.13; 95% CI: 0.96–1.33), but not significantly so, and the use of opiate or regional anaesthesia was significantly less likely (Table 4). Episiotomy was also significantly less likely with care from midwives alone (Fig. 2). However, there was no significant difference in rates for the induction of labour, instrumental delivery or caesarean section (Table 4). The postpartum haemorrhage rate was not significantly lower with care from midwives alone and there was no significant difference between the groups in the rate of fetal or neonatal death, preterm birth or admission to the neonatal intensive care unit (Table 4).
Fig. 2. Forest plot showing the risk of episiotomy when pregnancy care is provided only by midwives versus when it is provided by obstetricians or other types of doctors as part of a team including midwives, 1993–2012
In one study, women were significantly more satisfied with antenatal care provided by midwives alone but there was no significant difference between the groups in satisfaction with intrapartum or postpartum care.31 Turnball et al.30 also reported that women were more satisfied with care from midwives alone than care from doctors working with midwives in a team. Wolke et al.33 compared the level of satisfaction with health workers in general between groups of patients managed by midwives and those managed by junior paediatricians: the care provided by midwives was perceived as being significantly better than that provided by physicians (RR: 1.23; 95% CI: 1.10–1.37).
Four of the 53 studies34–37 compared auxiliary nurse midwives with doctors. There was no significant difference in the likelihood of an incomplete abortion between groups of patients managed by auxiliary nurse midwives and those managed by doctors (RR: 0.93; 95% CI: 0.45–1.90). Nor was the likelihood of a complication during (RR: 3.07; 95% CI: 0.16–59.1) – or an adverse event after (RR: 1.36; 95% CI: 0.54–3.40) – manual vacuum aspiration significantly greater with auxiliary nurse midwives. Similarly, there was no difference between the groups in postoperative complications in women who underwent tubal ligation or in those who were referred to a specialist after insertion of an intrauterine device (Table 4).
One study38 compared the effects of antiretroviral therapy (ART) in patients managed by nurses and those managed by doctors. There was no significant difference in the likelihood of ART failure between groups of patients managed by nurses and those managed by doctors (RR: 1.08; 95% CI: 0.39–2.14). Nor was there any difference in mortality, failure of viral suppression or immune recovery between the groups.
The search also identified one study39 that compared nursing care of depression in the general population with standard care. There was no significant difference in measures of depression between patients managed by nurses compared with those managed by physicians (RR: 1.28; 95% CI: 0.83–1.98).
Twenty-eight studies40–45,47–51,53–69 compared the effectiveness of care provided by nurses and care provided by doctors in patients with chronic diseases, such as heart disease and diabetes. Most concerned secondary and tertiary care in developed countries. The meta-analysis showed that care provided by nurses was as effective as care provided by doctors: no significant difference between the groups was found in the need for a repeat consultation, improved physical functioning, attendance at follow-up visits or attendance at an emergency department after receiving care (Table 4). However, dissatisfaction was significantly lower with care received from nurses than with that received from doctors (RR: 0.20; 95% CI: 0.14–0.26). The likelihood of death at 12-month follow-up was also lower with care from nurses and the likelihood of compliance with drug treatment was higher (Table 4). However, these last two findings are based on the results of only one study.
All of the lower quality, prospective observational studies identified came from Africa and compared care delivered by clinical officers, surgical technicians or non-physician clinicians with that delivered by doctors.
Six observational studies compared the effectiveness of care provided by clinical officers and surgical technicians with that of care provided by doctors.70–75 Detailed descriptions of the interventions and types of mid-level health workers involved in these studies are provided in Table 5 (available at: http://www.who.int/bulletin/volumes/91/11/13-118786). Since the studies were not experimental in design, data could not be pooled for analysis. Two studies from Malawi compared the outcomes of surgical procedures carried out by clinical officers and medical officers (i.e. doctors).70,71 In the prospective cohort study from Malawi, there was no significant difference in postoperative maternal health outcomes, such as fever, wound infection, the need for re-operation and maternal death, after emergency obstetric procedures performed by clinical officers or by medical officers (RR: 0.99; 95% CI: 0.95–1.03). In particular, there was no significant difference in the likelihood of a stillbirth with procedures performed by clinical officers (RR: 0.75; 95% CI: 0.52–1.09) or in the likelihood of early neonatal death (RR: 1.40; 95% CI: 0.51–3.87). Although 22 maternal deaths occurred in 1875 procedures performed by clinical officers compared with 1 in 256 procedures performed by medical officers, the difference was not significant. In a prospective cohort study from Mozambique,72 haematomas occurred significantly more often after surgery performed by a surgical technician than after surgery performed by an obstetrician (odds ratio: 2.2; 95% CI: 1.3–3.9). Finally, a retrospective cohort study from the United Republic of Tanzania73 found no difference in maternal mortality or perinatal mortality between care provided by an assistant medical officer and that provided by a medical officer.
The meta-analysis showed that the outcomes of numerous interventions in the areas of maternal and child health and communicable and noncommunicable diseases were similar when the interventions were performed by mid-level health workers or higher level health workers. However, this finding must be interpreted with caution as the evidence obtained in the systematic review was generally of low or very low quality.
Mid-level health workers play an important role in maternal and child health since midwives are the primary health-care providers in many settings. The results of our meta-analysis indicate that antenatal care provided by midwives alone gave comparable results on most outcome measures to care provided by doctors working in a team with midwives. In addition, mothers were more satisfied with neonatal examinations performed by midwives alone. Midwives can provide continuity of care after childbirth and can advise mothers on other health-care issues concerning neonates, such as breastfeeding.
Mid-level health workers often care for patients with chronic conditions such as diabetes mellitus and hypertension. Our meta-analysis indicated that patients were significantly more satisfied with care received from nurses than from doctors, though the evidence available was of low quality. Moreover, care provided by nurses was as effective as that provided by doctors. Another consideration is that consultations with mid-level health workers are less expensive for patients.
If health-related Millennium Development Goals are to be achieved, health systems will have to be strengthened so that more countries can deliver a wider range of health services on a much larger scale. It has been claimed that better quality health services could be achieved using the existing workforce, but there is compelling evidence that the number of people with access to health-care services is directly correlated with the number of health service providers.76 Furthermore, there is also a correlation between the health of the population and the density of qualified health-care workers.77 Thus, the number of health-care workers has a positive effect not only on access to health care but also on health outcomes. Clearly, any strategy that aims to increase the scope or reach of the health-care services must consider long-, medium- and short-term initiatives for increasing the skills and retention of health-care workers.
Although the use of mid-level health workers instead of medical doctors has proved successful in various contexts, such as in performing surgery, providing health-care services, health promotion and education and providing ART, the quality of care can be poor when mid-level health workers are not properly supervised or are inadequately trained.78 Moreover, these factors can also have a negative effect on staff retention. Once it has been accepted that less-qualified health-care workers can provide as good a service as more qualified workers, attention should shift to optimizing the skills mix of the workforce. This would mitigate the effect of personnel shortages and help countries achieve the Millennium Development Goals.
This meta-analysis provides evidence supporting the concept of task-sharing, which is defined as the situation in which health-care tasks are shared, as part of a team-based approach to the delivery of care, with either existing or new health workers who have been trained for only a limited period or within only a narrow field. Task-sharing can help achieve the new paradigm of universal health coverage as well as health-related Millennium Development Goals. In addition, mid-level health workers are less costly to train and employ than doctors and they are easier to retain in rural areas. However, it must be remembered that task-sharing alone cannot produce large-scale changes where there is a shortage of personnel. Any task-sharing strategy should be implemented alongside other strategies designed to increase the total number of health-care workers.79–82
The main obstacle to ensuring that mid-level health workers can help improve health outcomes is that they are often ignored by government policies, health workforce strategies and health system support measures, despite their widespread use. Until these workers are more comprehensively taken into account and supported, their potential contribution will not be fully realized.
This review has several limitations. First, most studies reviewed did not fully describe the characteristics of the mid-level health workers involved; in particular, the level and amount of training and supervision provided were not reported. Second, the meta-analysis included few studies of the role of mid-level health workers in HIV prevention and care, mental health or nutrition. Third, the quality of the evidence in the studies we identified was low or very low and, in particular, the majority of studies from Africa on non-physician clinicians and clinical officers were not experimental. Therefore, the results of these studies could not be pooled to generate evidence on the effectiveness of mid-level health workers.
There is a need for more studies of a high methodological quality, particularly experimental studies in primary health care and developing countries. In addition, further research is required on the effectiveness of mid-level health workers in low- and middle- income settings, where the challenge of accessing essential health services is greatest. There is also a remarkable dearth of information on the cost-effectiveness of programmes involving these health workers and on whether these programmes help ensure that care can be accessed on an equitable basis. Finally, there is a need for a systematic review to identify factors that determine whether interventions involving mid-level health workers are sustainable when scaled-up.
In conclusion, we found no difference between the effectiveness of care provided by mid-level health workers and that provided by higher level health workers. However, the quality of the evidence was low or very low. Better quality trials with longer follow-ups are needed, particularly in Africa. Countries in danger of missing health-related Millennium Development Goals should continue to scale up health-care interventions involving community health workers and mid-level health workers. Both national and subnational policies are needed to reduce the shortfall in human resources for health: the skills required by mid-level health workers and their roles should be clearly defined with reference to the level of demand from the local community and changing disease patterns in the country.
The review was supported financially by the Global Health Workforce Alliance.
- Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, et al., Maternal and Child Undernutrition Study Group, et al. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008; 371: 417-40 http://dx.doi.org/10.1016/S0140-6736(07)61693-6 pmid: 18206226.
- Bhutta ZA, Ali S, Cousens S, Ali TM, Haider BA, Rizvi A, et al., et al. Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make? Lancet 2008; 372: 972-89 http://dx.doi.org/10.1016/S0140-6736(08)61407-5 pmid: 18790320.
- Bhutta ZA, Darmstadt GL, Haws RA, Yakoob MY, Lawn JE. Delivering interventions to reduce the global burden of stillbirths: improving service supply and community demand. BMC Pregnancy Childbirth 2009; 9: S7 http://dx.doi.org/10.1186/1471-2393-9-S1-S7 pmid: 19426470.
- Campbell OMR, Graham WJ. Lancet Maternal Survival Series steering group. Strategies for reducing maternal mortality: getting on with what works. Lancet 2006; 368: 1284-99 http://dx.doi.org/10.1016/S0140-6736(06)69381-1 pmid: 17027735.
- Kerber KJ, de Graft-Johnson JE, Bhutta ZA, Okong P, Starrs A, Lawn JE. Continuum of care for maternal, newborn, and child health: from slogan to service delivery. Lancet 2007; 370: 1358-69 http://dx.doi.org/10.1016/S0140-6736(07)61578-5 pmid: 17933651.
- Haws RA, Thomas AL, Bhutta ZA, Darmstadt GL. Impact of packaged interventions on neonatal health: a review of the evidence. Health Policy Plan 2007; 22: 193-215 http://dx.doi.org/10.1093/heapol/czm009 pmid: 17526641.
- Resolution A/RES.33/63. Global health and foreign policy. In: General Assembly of the United Nations [Internet]. Resolutions. New York: WHO; 2013 (A/RES/33/63). Available from: http://www.who.int/trade/foreignpolicy/en/ [accessed 26 August 2013].
- Mid-level and nurse practitioners in the Pacific: models and issues. Manila: World Health Organization, Western Pacific Regional Office; 2001. Available from: http://whqlibdoc.who.int/wpro/2001/a76187.pdf [accessed 26 August 2013].
- Dovlo D. Using mid-level cadres as substitutes for internationally mobile health professionals in Africa: a desk review. Hum Resour Health 2004; 2: 7.
- Lehman U. Mid-level health workers. The state of the evidence on programmes, activities, costs and impact on health outcomes: a literature review. Geneva: World Health Organization; 2008. Available from: http://www.who.int/hrh/MLHW_review_2008.pdf [accessed 26 August 2013].
- Task shifting to tackle health worker shortages. Geneva: World Health Organization; 2007. Available from: www.who.int/healthsystems/task_shifting_booklet.pdf [accessed 26 August 2013].
- Zulu l. Clinical officers (CO) and health care delivery in Zambia: a response to physician shortage. Lusaka: CDC Global AIDS Program. Available from: http://csis.org/files/media/csis/events/080324_zulu.pdf [accessed 4 July 2013].
- Hounton SH, Newlands D, Meda N, De Brouwere V. A cost-effectiveness study of caesarean-section deliveries by clinical officers, general practitioners and obstetricians in Burkina Faso. Hum Resour Health 2009; 7: 34 http://dx.doi.org/10.1186/1478-4491-7-34 pmid: 19371433.
- Kruk ME, Pereira C, Vaz F, Bergström S, Galea S. Economic evaluation of surgically trained assistant medical officers in performing major obstetric surgery in Mozambique. BJOG 2007; 114: 1253-60 http://dx.doi.org/10.1111/j.1471-0528.2007.01443.x pmid: 17877677.
- Pereira C, Cumbi A, Malalane R, Vaz F, McCord C, Bacci A, et al., et al. Meeting the need for emergency obstetric care in Mozambique: work performance and histories of medical doctors and assistant medical officers trained for surgery. BJOG 2007; 114: 1530-3 http://dx.doi.org/10.1111/j.1471-0528.2007.01489.x pmid: 17877775.
- Optimizing the delivery of key interventions to attain MDGs 4 and 5: background document for the first expert ‘scoping’ meeting to develop WHO recommendations to optimize health workers’ roles to improve maternal and newborn health. Geneva: World Health Organization; 2010.
- Mullan F, Frehywot S. Non-physician clinicians in 47 sub-Saharan African countries. Lancet 2007; 370: 2158-63.
- Ottawa Hospital Research Institute [Internet]. EPOC resources. Suggested risk of bias criteria for EPOC reviews. Ottawa: OHRI; 2013. Available from: http://epoc.cochrane.org/search/google-appliance/Suggested%20risk%20of%20bias%20criteria [accessed 26 August 2013].
- Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ, GRADE Working Group. What is “quality of evidence” and why is it important to clinicians? BMJ 2008; 336: 995-8 http://dx.doi.org/10.1136/bmj.39490.551019.BE pmid: 18456631.
- Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Oxford: The Cochrane Collaboration; 2011. Available from: www.cochrane-handbook.org [accessed 26 August 2013].
- Begley C, Devane D, Clarke M, McCann C, Hughes P, Reilly M, et al., et al. Comparison of midwife-led and consultant-led care of healthy women at low risk of childbirth complications in the Republic of Ireland: a randomised trial. BMC Pregnancy Childbirth 2011; 11: 85 http://dx.doi.org/10.1186/1471-2393-11-85 pmid: 22035427.
- Harvey S, Jarrell J, Brant R, Stainton C, Rach DA. A randomized, controlled trial of nurse-midwifery care. Birth 1996; 23: 128-35 http://dx.doi.org/10.1111/j.1523-536X.1996.tb00473.x pmid: 8924098.
- Hundley VA, Cruickshank FM, Lang GD, Glazener CMA, Milne JM, Turner M, et al., et al. Midwife managed delivery unit: a randomised controlled comparison with consultant led care. BMJ 1994; 309: 1400-4 http://dx.doi.org/10.1136/bmj.309.6966.1400 pmid: 7819846.
- MacVicar J, Dobbie G, Owen-Johnstone L, Jagger C, Hopkins M, Kennedy J. Simulated home delivery in hospital: a randomised controlled trial. Br J Obstet Gynaecol 1993; 100: 316-23 http://dx.doi.org/10.1111/j.1471-0528.1993.tb12972.x pmid: 8494832.
- Marks MN, Siddle K, Warwick C. Can we prevent postnatal depression? A randomized controlled trial to assess the effect of continuity of midwifery care on rates of postnatal depression in high-risk women. J Matern Fetal Neonatal Med 2003; 13: 119-27 http://dx.doi.org/10.1080/jmf.184.108.40.206 pmid: 12735413.
- McLachlan HL, Forster DA, Davey M-A, Lumley J, Farrell T, Oats J, et al., et al. COSMOS: Comparing standard maternity care with one-to-one midwifery support: a randomised controlled trial. BMC Pregnancy Childbirth 2008; 8: 35 http://dx.doi.org/10.1186/1471-2393-8-35 pmid: 18680606.
- Di Napoli A, Di Lallo D, Fortes C, Franceschelli C, Armeni E, Guasticchi G. Home breastfeeding support by health professionals: findings of a randomized controlled trial in a population of Italian women. Acta Paediatr 2004; 93: 1108-14 http://dx.doi.org/10.1111/j.1651-2227.2004.tb02725.x pmid: 15456204.
- Rowley MJ, Hensley MJ, Brinsmead MW, Wlodarczyk JH. Continuity of care by a midwife team versus routine care during pregnancy and birth: a randomised trial. Med J Aust 1995; 163: 289-93 pmid: 7565233.
- Small R, Lumley J, Donohue L, Potter A, Waldenström U. Randomised controlled trial of midwife led debriefing to reduce maternal depression after operative childbirth. BMJ 2000; 321: 1043-7 http://dx.doi.org/10.1136/bmj.321.7268.1043 pmid: 11053173.
- Turnbull D, Holmes A, Shields N, Cheyne H, Twaddle S, Gilmour WH, et al., et al. Randomised, controlled trial of efficacy of midwife-managed care. Lancet 1996; 348: 213-8 http://dx.doi.org/10.1016/S0140-6736(95)11207-3 pmid: 8684197.
- Waldenström U, McLachlan H, Forster D, Brennecke S, Brown S. Team midwife care: maternal and infant outcomes. Aust N Z J Obstet Gynaecol 2001; 41: 257-64 http://dx.doi.org/10.1111/j.1479-828X.2001.tb01225.x pmid: 11592538.
- Law YYH, Lam KY. A randomized controlled trial comparing midwife-managed care and obstetrician-managed care for women assessed to be at low risk in the initial intrapartum period. J Obstet Gynaecol Res 1999; 25: 107-12 http://dx.doi.org/10.1111/j.1447-0756.1999.tb01131.x pmid: 10379125.
- Wolke D, Dave S, Hayes J, Townsend J, Tomlin M. Routine examination of the newborn and maternal satisfaction: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2002; 86: F155-60 http://dx.doi.org/10.1136/fn.86.3.F155 pmid: 11978744.
- Eren N, Ramos R, Gray RH. Physicians vs. auxiliary nurse-midwives as providers of IUD services: a study in Turkey and the Philippines. Stud Fam Plann 1983; 14: 43-7 http://dx.doi.org/10.2307/1965401 pmid: 6836665.
- Dusitsin N, Chalapati S, Varakamin S, Boonsiri B, Ningsanon P, Gray RH. Post-partum tubal ligation by nurse-midwives and doctors in Thailand. Lancet 1980; 1: 638-9 http://dx.doi.org/10.1016/S0140-6736(80)91129-0 pmid: 6102637.
- Warriner IK, Meirik O, Hoffman M, Morroni C, Harries J, My Huong NT, et al., et al. Rates of complication in first-trimester manual vacuum aspiration abortion done by doctors and mid-level providers in South Africa and Vietnam: a randomised controlled equivalence trial. Lancet 2006; 368: 1965-72 http://dx.doi.org/10.1016/S0140-6736(06)69742-0 pmid: 17141703.
- Warriner IK, Wang D, Huong NT, Thapa K, Tamang A, Shah I, et al., et al. Can midlevel health-care providers administer early medical abortion as safely and effectively as doctors? A randomised controlled equivalence trial in Nepal. Lancet 2011; 377: 1155-61 http://dx.doi.org/10.1016/S0140-6736(10)62229-5 pmid: 21458058.
- Sanne I, Orrell C, Fox M, Conradie F, Ive P, Zeinecker J, et al., et al. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet 2010; 376: 33-40 http://dx.doi.org/10.1016/S0140-6736(10)60894-X pmid: 20557927.
- Mann AH, Blizard R, Murray J, Smith JA, Botega N, MacDonald E, et al., et al. An evaluation of practice nurses working with general practitioners to treat people with depression. Br J Gen Pract 1998; 48: 875-9 pmid: 9604408.
- Du Moulin MF, Hamers JPH, Paulus A, Berendsen CL, Halfens R. Effects of introducing a specialized nurse in the care of community-dwelling women suffering from urinary incontinence: a randomized controlled trial. J Wound Ostomy Continence Nurs 2007; 34: 631-40 http://dx.doi.org/10.1097/01.WON.0000299814.98230.13 pmid: 18030102.
- Gordon DW. Health maintenance service: ambulatory patient care in the general medical clinic. Med Care 1974; 12: 648-58 http://dx.doi.org/10.1097/00005650-197408000-00003 pmid: 4852229.
- Hemani A, Rastegar DA, Hill C, al-Ibrahim MS. A comparison of resource utilization in nurse practitioners and physicians. Eff Clin Pract 1999; 2: 258-65 pmid: 10788023.
- Katz DA, Brown RB, Muehlenbruch DR, Fiore MC, Baker TB, AHRQ Smoking Cessation Guideline Study Group. Implementing guidelines for smoking cessation: comparing the efforts of nurses and medical assistants. Am J Prev Med 2004; 27: 411-6 pmid: 15556742.
- Kinnersley P, Anderson E, Parry K, Clement J, Archard L, Turton P, et al., et al. Randomised controlled trial of nurse practitioner versus general practitioner care for patients requesting “same day” consultations in primary care. BMJ 2000; 320: 1043-8 http://dx.doi.org/10.1136/bmj.320.7241.1043 pmid: 10764366.
- Strömberg A, Mårtensson J, Fridlund B, Levin LÃ, Karlsson J-E, Dahlström U. Nurse-led heart failure clinics improve survival and self-care behaviour in patients with heart failure: results from a prospective, randomised trial. Eur Heart J 2003; 24: 1014-23 http://dx.doi.org/10.1016/S0195-668X(03)00112-X pmid: 12788301.
- Mårtensson J, Strömberg A, Dahlström U, Karlsson JE, Fridlund B. Patients with heart failure in primary health care: effects of a nurse-led intervention on health-related quality of life and depression. Eur J Heart Fail 2005; 7: 393-403 http://dx.doi.org/10.1016/j.ejheart.2004.01.016 pmid: 15718180.
- Moher M, Yudkin P, Wright L, Turner R, Fuller A, Schofield T, et al., et al. Cluster randomised controlled trial to compare three methods of promoting secondary prevention of coronary heart disease in primary care. BMJ 2001; 322: 1338 http://dx.doi.org/10.1136/bmj.322.7298.1338 pmid: 11387182.
- Sakr M, Angus J, Perrin J, Nixon C, Nicholl J, Wardrope J. Care of minor injuries by emergency nurse practitioners or junior doctors: a randomised controlled trial. Lancet 1999; 354: 1321-6 http://dx.doi.org/10.1016/S0140-6736(99)02447-2 pmid: 10533859.
- Smith JR, Mildenhall S, Noble MJ, Shepstone L, Koutantji M, Mugford M, et al., et al. The Coping with Asthma Study: a randomised controlled trial of a home based, nurse led psychoeducational intervention for adults at risk of adverse asthma outcomes. Thorax 2005; 60: 1003-11 http://dx.doi.org/10.1136/thx.2005.043877 pmid: 16055616.
- Stein GH. The use of a nurse practitioner in the management of patients with diabetes mellitus. Med Care 1974; 12: 885-90 http://dx.doi.org/10.1097/00005650-197410000-00008 pmid: 4437220.
- Chambers LW, Bruce-Lockhart P, Black DP, Sampson E, Burke M. A controlled trial of the impact of the family practice nurse on volume, quality, and cost of rural health services. Med Care 1977; 15: 971-81 http://dx.doi.org/10.1097/00005650-197712000-00001 pmid: 592915.
- Black DP, Riddle RJ, Sampson E. Pilot project: the family practice nurse in a Newfoundland rural area. Can Med Assoc J 1976; 114: 945-7 pmid: 1268779.
- Caine N, Sharples LD, Hollingworth W, French J, Keogan M, Exley A, et al., et al. A randomised controlled crossover trial of nurse practitioner versus doctor-led outpatient care in a bronchiectasis clinic. Health Technol Assess 2002; 6: 1-71 pmid: 12433318.
- Chambers LW, West AE. The St John’s randomized trial of the family practice nurse: health outcomes of patients. Int J Epidemiol 1978; 7: 153-61 http://dx.doi.org/10.1093/ije/7.2.153 pmid: 681061.
- Chinn DJ, Poyner T, Sibley G. Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema. Br J Dermatol 2002; 146: 432-9 http://dx.doi.org/10.1046/j.1365-2133.2002.04603.x pmid: 11952543.
- Cox C, Jones M. An evaluation of the management of patients with sore throats by practice nurses and GPs. Br J Gen Pract 2000; 50: 872-6 pmid: 11141872.
- D’Eramo-Melkus G, Spollett G, Jefferson V, Chyun D, Tuohy B, Robinson T, et al., et al. A culturally competent intervention of education and care for black women with type 2 diabetes. Appl Nurs Res 2004; 17: 10-20 http://dx.doi.org/10.1016/j.apnr.2003.10.009 pmid: 14991551.
- Dierick-van Daele ATM, Metsemakers JFM, Derckx EWCC, Spreeuwenberg C, Vrijhoef HJM. Nurse practitioners substituting for general practitioners: randomized controlled trial. J Adv Nurs 2009; 65: 391-401 http://dx.doi.org/10.1111/j.1365-2648.2008.04888.x pmid: 19191937.
- Federman DG, Krishnamurthy R, Kancir S, Goulet J, Justice A. Relationship between provider type and the attainment of treatment goals in primary care. Am J Manag Care 2005; 11: 561-6 pmid: 16159046.
- Houweling ST, Kleefstra N, van Hateren KJ, Kooy A, Groenier KH, Ten Vergert E, et al., Langerhans Medical Research Group, et al. Diabetes specialist nurse as main care provider for patients with type 2 diabetes. Neth J Med 2009; 67: 279-84 pmid: 19687522.
- Mundinger MO, Kane RL, Lenz ER, Totten AM, Tsai W-Y, Cleary PD, et al., et al. Primary care outcomes in patients treated by nurse practitioners or physicians: a randomized trial. JAMA 2000; 283: 59-68 http://dx.doi.org/10.1001/jama.283.1.59 pmid: 10632281.
- Myers PC, Lenci B, Sheldon MG. A nurse practitioner as the first point of contact for urgent medical problems in a general practice setting. Fam Pract 1997; 14: 492-7 http://dx.doi.org/10.1093/fampra/14.6.492 pmid: 9476082.
- Rushforth H, Burge D, Mullee M, Jones S, McDonald H, Glasper EA. Nurse-led paediatric preoperative assessment: an equivalence study. Paediatr Nurs 2006; 18: 23-9 pmid: 16634381.
- Sharples LD, Edmunds J, Bilton D, Hollingworth W, Caine N, Keogan M, et al., et al. A randomised controlled crossover trial of nurse practitioner versus doctor led outpatient care in a bronchiectasis clinic. Thorax 2002; 57: 661-6 http://dx.doi.org/10.1136/thorax.57.8.661 pmid: 12149523.
- Shum C, Humphreys A, Wheeler D, Cochrane M-A, Skoda S, Clement S. Nurse management of patients with minor illnesses in general practice: multicentre, randomised controlled trial. BMJ 2000; 320: 1038-43 http://dx.doi.org/10.1136/bmj.320.7241.1038 pmid: 10764365.
- Venning P, Durie A, Roland M, Roberts C, Leese B. Randomised controlled trial comparing cost effectiveness of general practitioners and nurse practitioners in primary care. BMJ 2000; 320: 1048-53 http://dx.doi.org/10.1136/bmj.320.7241.1048 pmid: 10764367.
- Sackett DL, Spitzer WO, Gent M, Roberts RS. The Burlington randomized trial of the nurse practitioner: health outcomes of patients. Ann Intern Med 1974; 80: 137-42.
- Babor TE, Higgins-Biddle J, Dauser D, Higgins P, Burleson JA. Alcohol screening and brief intervention in primary care settings: implementation models and predictors. J Stud Alcohol 2005; 66: 361-8 pmid: 16047525.
- McIntosh MC, Leigh G, Baldwin NJ, Marmulak J. Reducing alcohol consumption. Comparing three brief methods in family practice. Can Fam Physician 1997; 43: 1959-62 pmid: 9386883.
- Chilopora G, Pereira C, Kamwendo F, Chimbiri A, Malunga E, Bergström S. Postoperative outcome of caesarean sections and other major emergency obstetric surgery by clinical officers and medical officers in Malawi. Hum Resour Health 2007; 5: 17 http://dx.doi.org/10.1186/1478-4491-5-17 pmid: 17570847.
- McGuire M, Goossens S, Kukasha W, Ahoua L, Pujades M, Le Paih M, et al. Nurses and medical assistants taking charge: task-shifting HIV care and HAART initiation in resource-constrained and rural Malawi. In: XVII International AIDS Conference, 3–8 August 2008 Mexico City, Mexico [Internet]. Available from: http://www.doctorswithoutborders.org/events/symposiums/2008-aids-iac/assets/files/Nurses-and-medical-assistants-taking-charge.pdf [accessed 26 August 2013].
- Pereira C, Bugalho A, Bergström S, Vaz F, Cotiro M. A comparative study of caesarean deliveries by assistant medical officers and obstetricians in Mozambique. Br J Obstet Gynaecol 1996; 103: 508-12 http://dx.doi.org/10.1111/j.1471-0528.1996.tb09797.x pmid: 8645640.
- McCord C, Mbaruku G, Pereira C, Nzabuhakwa C, Bergstrom S. The quality of emergency obstetrical surgery by assistant medical officers in Tanzanian district hospitals. Health Aff (Millwood) 2009; 28: w876-85 http://dx.doi.org/10.1377/hlthaff.28.5.w876 pmid: 19661113.
- Gimbel-Sherr K, Augusto O, Micek M, Gimbel-Sherr S, Tomo MI, Pfeiffer J, et al. Task shifting to mid-level clinical health providers: an evaluation of quality of ART provided by tecnicos de medicina and physicians in Mozambique. In: XVII International AIDS Conference, 3–8 August 2008, Mexico City, Mexico [Internet]. Available from: http://www.aids2008.org/pag/PSession.aspx?s=321 [accessed 26 August 2013].
- Labhardt ND, Balo JR, Ndam M, Grimm JJ, Manga E. Task shifting to non-physician clinicians for integrated management of hypertension and diabetes in rural Cameroon: a programme assessment at two years. BMC Health Serv Res 2010; 10: 339 http://dx.doi.org/10.1186/1472-6963-10-339 pmid: 21144064.
- Anand S, Bärnighausen T. Health workers and vaccination coverage in developing countries: an econometric analysis. Lancet 2007; 369: 1277-85 http://dx.doi.org/10.1016/S0140-6736(07)60599-6 pmid: 17434403.
- Anand S, Bärnighausen T. Human resources and health outcomes: cross-country econometric study. Lancet 2004; 364: 1603-9 http://dx.doi.org/10.1016/S0140-6736(04)17313-3 pmid: 15519630.
- Munga MA, Kilima SP, Mutalemwa PP, Kisoka WJ, Malecela MN. Experiences, opportunities and challenges of implementing task shifting in underserved remote settings: the case of Kongwa district, central Tanzania. BMC Int Health Hum Rights 2012; 12: 27 http://dx.doi.org/10.1186/1472-698X-12-27 pmid: 23122296.
- Task shifting: rational redistribution of tasks among health workforce teams; global recommendations and guidelines. Geneva: World Health Organization; 2008. Available from: http://chwcentral.org/sites/default/files/Task%20Shifting-%20Global%20Recommendations%20and%20Guidelines.pdf [accessed 26 August 2013].
- Huicho L, Miranda JJ, Diez-Canseco F, Lema C, Lescano AG, Lagarde M, et al., et al. Job preferences of nurses and midwives for taking up a rural job in Peru: a discrete choice experiment. PLoS ONE 2012; 7: e50315 http://dx.doi.org/10.1371/journal.pone.0050315 pmid: 23284636.
- Miranda JJ, Diez-Canseco F, Lema C, Lescano AG, Lagarde M, Blaauw D, et al., et al. Stated preferences of doctors for choosing a job in rural areas of Peru: a discrete choice experiment. PLoS ONE 2012; 7: e50567 http://dx.doi.org/10.1371/journal.pone.0050567 pmid: 23272065.
- Lagarde M, Pagaiya N, Tangcharoensathian V, Blaauw D. One size does not fit all: investigating doctors’ stated preference heterogeneity for job incentives to inform policy in Thailand. Health Econ 2013Epub 24 January 2013 http://dx.doi.org/10.1002/hec.2897 pmid: 23349119.