Implications of adopting new WHO guidelines for antiretroviral therapy initiation in Ethiopia
Elke Konings a, Yirga Ambaw b, Katherine Dilley a, Peter Gichangi b, Tesfaye Arega a & Bud Crandall a
a. Management Sciences for Health, 784 Memorial Drive, Cambridge, MA, 01230, United States of America.
b. United States Agency for International Development Ethiopia, Addis Ababa, Ethiopia.
Correspondence to Elke Konings (e-mail: firstname.lastname@example.org).
(Submitted: 25 April 2011 – Revised version received: 29 April 2012 – Accepted: 11 May 2012 – Published online: 25 June 2012.)
Bulletin of the World Health Organization 2012;90:659-663. doi: 10.2471/BLT.11.089599
In 2010, the World Health Organization (WHO) issued new guidelines for the initiation of antiretroviral therapy (ART) in adults and adolescents with human immunodeficiency virus (HIV) infection. The guidelines cover a range of issues associated with ART, including initiation of the regimen at an earlier stage of infection, updated first- and second-line drug regimens and improved criteria for switching antiretrovirals.1 This paper focuses on the CD4+ T-lymphocyte (CD4+) count used as the clinical threshold for initiating ART, which has been shifted to ≤ 350 cells/mm3 from the former standard, ≤ 200 cells /mm3.
Studies and modelling exercises suggest that HIV-related mortality could be reduced by 20% between 2010 and 2015 by raising the CD4+ cell threshold required for initiating ART. Another possible benefit would be reduced HIV transmission between couples and from mother to child. An increase in the CD4+ threshold and hence in the demand for treatment entails certain risks, however: a rise in treatment costs as high as 57%; the displacement of patients in urgent need of ART; longer exposure to ART, resulting in unknown side-effects and in the development of resistance mechanisms. WHO has declared that in making these revisions, a high value, over and above cost and feasibility, was placed on avoiding death, disease progression and HIV transmission.1 However, implementing these guidelines is not always possible in the countries where ART is most needed.
Some studies on the feasibility of implementing WHO guidelines in resource-constrained settings have been conducted, and many of them have shown that in such settings health system constraints make it difficult to roll out the new WHO guidelines.2,3 According to one model-based analysis that projected clinical and economic outcomes in a South African HIV-infected cohort, initiation of ART in patients with a CD4+ count of ≤ 350 cells/mm3 provides the greatest short- and long-term survival advantage and is also highly cost-effective.2 Other studies that have explored how health system constraints impeded the roll-out of the 2006 WHO guidelines count among the barriers ART stock-outs, lack of capability for performing CD4+ counts and human resource shortages. The same factors are obviously applicable to the new 2010 guidelines.4,5
If countries are to adopt the new WHO guidelines, the health system will have to be equipped to conduct more HIV tests and CD4+ counts and health-care services will have to become capable of absorbing higher patient case-loads. A study using Cameroon, Kenya, Viet Nam and Zambia as examples demonstrated that the change in the CD4+ threshold for initiating ART would increase the number of patients requiring ART not only in the immediate future, but also in the long term.4
Context in Ethiopia
While the overall prevalence of HIV infection in Ethiopia, which is currently 2.1%, remains relatively low, the country is home to an estimated 1.1 million HIV-positive people.6,7 Ethiopia’s epidemic of HIV infection is marked by pockets of high prevalence in urban areas and among women. In 2009, the prevalence of HIV infection was 7.7% in urban areas (versus 0.9% in rural areas) and 2.8% among females (versus 1.8% among males).8 Less than one third of Ethiopia’s HIV-positive patients are currently enrolled in comprehensive care and support services. Of those among them who need ART, only 62% are receiving it, despite unprecedented government efforts in the past four years to rapidly scale up comprehensive care for patients with HIV infection and acquired immunodeficiency syndrome (AIDS) throughout the country.9
In response to the HIV/AIDS epidemic, the Government of Ethiopia made drastic policy shifts that set a precedent in sub-Saharan Africa. Comprehensive HIV/AIDS services, including ART, were made widely available free of charge to the country’s population of nearly 80 million people. To ensure the availability of these services, the government decentralized HIV patient care, which it transferred from physicians in hospitals to mid-level health-care workers in health centres. Nurses and health officers in health centres are also supported by the work of community health workers administering community-based and home-based care.
Unlike its neighbouring countries, Ethiopia has a good supply of ART drugs. The unmet need for ART in Ethiopia is caused not by a shortage of drugs, but by health system constraints. Many health centres do not have the equipment for conducting CD4+ counts and yet lack a vehicle for transporting samples quickly and safely to the nearest hospital having the required machine. Furthermore, hospitals are putting caps on the number of health centre samples processed. The health system also lacks mechanisms for tracking pre-ART patients. Plans are under way to introduce pre-ART registers and develop a routine appointment system to prevent losses to follow-up among these patients. Because of all these constraints, in Ethiopia some HIV-positive patients are started on ART on the basis of clinical staging without performing a CD4+ count, as a result of which some patients begin treatment when the count is already ≤ 200 cells/mm3.
If Ethiopia adopts the new WHO guidelines, ART will have to be initiated not solely on the basis of patients’ clinical staging, but early on in the course of HIV infection. To meet the new guidelines, Ethiopia will have to address current system constraints as well as ensure the availability of enough financial resources to provide ART for the influx of newly-eligible patients. To assess the implications of adopting the new guidelines, the Government of Ethiopia asked the HIV/AIDS Care and Support Program (HCSP), funded by the United States Agency for International Development, to conduct a study that would provide an estimate of the increase in patient case-load that this policy change would bring about.
CD4+ cell test results recorded on pre-ART and ART registers were collected from all pre-ART and ART patients at 19 high-patient-load health centres in Addis Ababa, capital of Ethiopia, and the regions of Amhara, Oromia, SNNPR (Southern Nations, Nationalities and People's Region) and Tigray between April and May 2010. The 19 health centres are part of a network of 350 ART health centres supported by the HCSP, Ethiopia’s main partner in decentralizing HIV/AIDS treatment to primary-health-care facilities. These 19 health centres offer a large representative sample of patients on ART in health centres in Ethiopia; they probably cover as many as 50% of all such patients.
At the 12 most accessible centres, patient records were independently reviewed after one month to assess data accuracy. Patients included adults as well as children aged 6 years or older. The Ethiopian national ART guidelines recommend testing children aged 6 years and older and prescribing ART according to the same criteria as for adults. To estimate the total number of patients who would need ART at health centres if Ethiopia adopted the new WHO guidelines, the number of patients needing ART based on current guidelines (CD4+ count ≤ 200 cells/mm3 and symptomatic, stages III or IV) were added to the number of asymptomatic patients enrolled in pre-ART with a CD4+ count > 200 but ≤ 350 cells/mm3. In Ethiopia, CD4+ counts are performed with a fluorescence-activated cell sorter.
A total of 9824 HIV-positive patients (male: 3283; female: 6533; sex unknown: 8) were enrolled in care and support in the 19 study health centres at the time of data collection. Among them were 5066 pre-ART patients (male: 1613; female: 3446; sex unknown: 7). The remaining 4758 patients (48.4%) were on ART (male: 1670; female: 3087; sex unknown: 1). The age of the patients was 31.7 years on average and ranged from 6 to 88 years. CD4+ test results were recorded for 79.6% of patients who had ever enrolled in pre-ART and for 79.0% of all patients receiving ART.
Of the patients for whom CD4+ data were available, 3583 met the current national guidelines for ART initiation (Table 1). Under the new WHO guidelines, the number of patients who would need ART would also include the 1057 asymptomatic patients with a CD4+ count > 200 but ≤ 350 cells/mm3. All else being equal, adoption of the new guidelines would increase the total number of ART patients at the 19 study health centres from 3583 to 4640, and 23% of the patients with HIV (infection) not currently receiving ART would have to start receiving it. This would correspond to a 30% increase in the total load of patients on ART.
Table 1. CD4+ T-lymphocyte (CD4+) profile of patients with human immunodeficiency virus (HIV) before starting antiretroviral therapy (pre ART) or while on ART, 19 health centres, Ethiopia, May 2010
A subset of patient records at the 12 most accessible health centres were independently verified one month after data collection. At four such health centres, 298 records were verified for staging. Of these, 8 (2.7%) records showed data errors. Data on patients with a CD4+ count of < 50 cells/mm3 were verified for all patients at eight health centres and for a random sample of 58 of 247 patients (24%) at the other four health centres. Of these patient records, 4.6% contained patient CD4+ counts that differed by more than 5% from the reported counts. If, for instance, the reported CD4+ count was 300 cells/mm3 and the recorded count was 400 cells/mm3, the difference between the two was 25%, a value above the 5% difference considered acceptable. Data on CD4+ counts ranging from 50 to 900 cells/mm3 were verified for 88 of 425 (21%) patients at one health centre; 2.3% of these records were found to contain CD4+ counts that deviated by more than 5% from the original data. Lastly, CD4+ counts > 900 cells/mm3 were verified for all patients at eight health centres and for 21 of 24 patients (88%) at the four additional health centres. The proportion of records showing a difference in CD4+ data of more than 5% was 3.1%. Overall, 5.3% of patient records were verified for data accuracy and 3.8% of these records deviated by more than 5% from the data collected originally.
Following its new recommendations for ART initiation, WHO supported a study in Malawi to assess the feasibility of adopting the new guidelines. The results of this rapid assessment in Malawi indicate that if the country adopts the new guidelines calling for ART initiation at a higher CD4+ count, it will have to rely on clinical staging primarily, since most ART facilities in Malawi do not have access to CD4+ counters. Data from several sites in Malawi suggest that patient case-loads could increase by as much as 40%, and this would result in waiting lists at ART sites. In its final recommendation, the report reiterated that without large injections of resources, guideline implementation could have crippling effects on the health system.10 Despite this, Malawi has moved to adopt the new guidelines and is aggressively working to address various challenges involving finances, infrastructure, supply-chain management and health worker shortage.
Ethiopia is rapidly expanding comprehensive HIV services to health centres. This relieves hospitals of a large patient load and makes services available to many more HIV-positive people in the country. Despite the current national guidelines on ART initiation, a substantial number of patients with HIV infection who need ART are not accessing it yet. Our study has shown, based on the number currently enrolled in ART, that by adopting the new WHO guidelines, the load of patients needing ART would be 30% higher than at present, although the treatment coverage of such patients would not increase accordingly. If the distributions of CD4+ counts found at health centres resemble those seen among the many HIV-positive patients who need ART but are not receiving it, this percentage remains valid, even if the current unmet need for ART is met.
Within health centres, our data verification showed that the study result is a valid and realistic estimate of the additional ART patient case-load that Ethiopia’s health centres may anticipate after the new WHO guidelines for ART initiation are implemented.
A 30% increase in ART patient case-load has important financial and logistical implications for Ethiopia. The average cost of treating a patient with a first-line antiretroviral drug is currently estimated at 190 United States dollars (US$) per year.11 If Ethiopia adopts the new WHO guidelines for ART initiation, it will need around US$ 127 million per year, as opposed to the annual sum of US$ 97.6 million it needs at present. Furthermore, the feasibility of adopting the new WHO guidelines in Ethiopia will have to be weighed against the limited absorptive capacity of Ethiopia’s health-care system and service providers.
This shift in the CD4+ threshold for ART initiation will only increase the demand for ART. With the systems currently in place, only 60% of eligible patients are receiving ART. Without concurrent increases in funding and governmental support, it will not be possible to scale up ART programmes to accommodate the increased patient demand in Ethiopia. These increased costs are not currently affordable for the Ethiopian Government, which has decided to continue to observe the 2006 ART guidelines. While the 2010 revision is sound in principle and value, resources in Ethiopia are not enough to absorb the ensuing increased demand for existing services.
Other resource-poor countries that have elected to implement the new WHO guidelines may face similar challenges and could benefit from an effort to estimate how much the change in policy would increase the load of patients needing ART. The results may prove useful for resource analysis and planning and for determining the feasibility of adopting the new WHO guidelines on ART initiation and the country’s readiness to do so.
- Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. 2010 revision. Geneva: World Health Organization, HIV/AIDS Programme; 2010.
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- Menon S. Early initiation of antiretroviral therapy and universal HIV testing in sub-Saharan Africa: has WHO offered a milestone for HIV prevention? J Public Health Policy 2010; 31: 385-400 doi: 10.1057/jphp.2010.29 pmid: 21119646.
- Hamilton A, Garcia-Calleja JM, Vitoria M, Gilks C, Souteyrand Y, De Cock K, et al., et al. Changes in antiretroviral therapy guidelines: implications for public health policy and public purses. Sex Transm Infect 2010; 86: 388-90 doi: 10.1136/sti.2010.043018 pmid: 20876757.
- Muhamadi L, Nsabagasani X, Tumwesigye MN, Wabwire-Mangen F, Ekström AM, Peterson S, et al., et al. Inadequate pre-antiretroviral care, stock-out of antiretroviral drugs and stigma: policy challenges/bottlenecks to the new WHO recommendations for earlier initiation of antiretroviral therapy (CD<350 cells/microL) in eastern Uganda. Health Policy 2010; 97: 187-94 doi: 10.1016/j.healthpol.2010.06.003 pmid: 20615573.
- Federal Ministry of Health. Single point HIV prevalence estimate, June 2007. Addis Ababa: Federal HIV/AIDS Prevention and Control Office; 2007.
- Federal Ministry of Health. Report on progress towards implementation of the UN Declaration of Commitment on HIV/AIDS. Addis Ababa: Federal HIV/AIDS Prevention and Control Office; 2010.
- Federal Ministry of Health. Strategic Plan for Intensifying Multisectoral HIV and AIDS Response in Ethiopia II (SPM II) 2009–2014. Addis Ababa: Federal HIV/AIDS Prevention and Control Office; 2009. Available from: http://www.google.ch/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=4&ved=0CFIQFjAD&url=http%3A%2F%2Fhivaidsclearinghouse.unesco.org%2Fsearch%2Fresources%2Fiiep_ethiopia_2010_strategic_plan_ii.pdf&ei=b1S2T-6WN4LNtAag-Li4CA&usg=AFQjCNG_lV6rQ0fazLsqFMNjE30yrif_Gg&sig2=QjhV2TCiVeMhhXqoyZ7pyA [accessed 18 May 2012].
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