Bulletin of the World Health Organization

Global disparities in the epilepsy treatment gap: a systematic review

Ana-Claire Meyer, Tarun Dua, Juliana Ma, Shekhar Saxena & Gretchen Birbeck

Volume 88, Number 4, April 2010, 260-266

Table 2. Studies used for estimating epilepsy treatment gap based on the lifetime prevalence of epilepsy, by country

  Country Location Year No. of cases % treatment gap Setting/population Author
Bangladesh Attempts to be representative of country; 3 rural, 2 urban areas 1992a 67 86 Mixed, children Durkin MS, Davidson L, Hasan K, Hasan Z, Hauser W, Khan N, et al. Estimates of the prevalence of childhood seizure disorders in communities where professional resources are scarce: results from Bangladesh, Jamaica and Pakistan. Paediatr Perinat Epidemiol 1992;6:166-80. doi:10.1111/j.1365-3016.1992.tb00758.x PMID:1584719
Bolivia Cordillera Province, Santa Cruz Department 1994 124 100 Rural Nicoletti A, Reggio A, Bartoloni A, Failla G, Sofia V, Bartalesi F, et al. Prevalence of epilepsy in rural Bolivia: a door-to-door survey. Neurology 1999;53:2064-9. PMID:10599782
Cameroon Bilomo, west bank of Mbam river in Centre Province of Cameroon 1998 93 32 Rural Njamnshi AK, Sini V, Djientcheu VDP, Ongolo-Zogo P, Mapoure Y, Yepnjio FN, et al. Risk factors associated with epilepsy in a rural area in Cameroon: A preliminary study. African J Neurol Sci 2007;26:18-26.
China 4 towns, 6 villages in Dongning County, Mundanjiang City, Heilongjiang Province 2000 81 36 Rural Ma GY, Li ZQ, Lu S, Wang LH, Wen SR, Li GZ, et al. Survey of etiological factors of epilepsy in Mudanjian rural population by randomly cluster sampling. Chin J Clin Rehabil 2004;8:3178-9.Tang Y, Li GZ, Ma GY, Wang DS. Epidemiological survey of epilepsy in Dongning county, a rural area in Heilongjiang Province of China. Chin J Clin Rehabil 2004;8:770-1.
Colombia Medellin 1983 77 73 Urban Zuloaga L, Soto C, Jaramillo D, Mora O, Betancur C, Londono R. [Prevalence of epilepsy in Medellin, Colombia, 1983]. Bol Oficina Sanit Panam 1988;104:331-44. PMID:2971372
France Haute-Vienne, Limousin region 1986–87 20 55 Mixed Munoz M, Boutros-Toni F, Preux PM, Chartier JP, Ndzanga E, Boa F, et al. Prevalence of neurological disorders in Haute-Vienne department (Limousin region-France). Neuroepidemiology 1995;14:193-8. doi:10.1159/000109796 PMID:7643954
Guatemala Small rural village 1996a 16 31 Rural Mendizabal JE, Salguero LF. Prevalence of epilepsy in a rural community of Guatemala. Epilepsia 1996;37:373-6. doi:10.1111/j.1528-1157.1996.tb00574.x PMID:8603643
India PHC cachement area, Haryana, North India 1992–4 126 53 Rural Singh A, Kaur A. Epilepsy in rural Haryana – prevalence and treatment seeking behaviour. J Indian Med Assoc 1997;95:37-9, 47. PMID:9357239
Italy Riposto (Catania Province); Santa Teresa di Riva (Messina Province); Terrasini (Palermo Province) Sicily 1987 111 39 Semi-urban Rocca WA, Savettieri G, Anderson DW, Meneghini F, Grigoletto F, Morgante L, et al. Door-to-door prevalence survey of epilepsy in three Sicilian municipalities. Neuroepidemiology 2001;20:237-41. doi:10.1159/000054796 PMID:11684899
Jamaica May Pen and Lionel Town, Clarendon parish 1992a 32 62 Rural, children Durkin MS, Davidson L, Hasan K, Hasan Z, Hauser W, Khan N, et al. Estimates of the prevalence of childhood seizure disorders in communities where professional resources are scarce: results from Bangladesh, Jamaica and Pakistan. Paediatr Perinat Epidemiol 1992;6:166-80. doi:10.1111/j.1365-3016.1992.tb00758.x PMID:1584719
Netherlands Elderly, Rotterdam Study 1991–1993 85 52 Suburb de la Court A, Breteler MM, Meinardi H, Hauser WA, Hofman A. Prevalence of epilepsy in the elderly: the Rotterdam Study. Epilepsia 1996;37:141-7. doi:10.1111/j.1528-1157.1996.tb00005.x PMID:8635424
Pakistan Greater Karachi; 43 urban and 16 rural 1992a 99 62 Mixed, children Durkin MS, Davidson L, Hasan K, Hasan Z, Hauser W, Khan N, et al. Estimates of the prevalence of childhood seizure disorders in communities where professional resources are scarce: results from Bangladesh, Jamaica and Pakistan. Paediatr Perinat Epidemiol 1992;6:166-80. doi:10.1111/j.1365-3016.1992.tb00758.x PMID:1584719
Singapore National 1995 89 6 National; 18 year old men Kun LN, Ling LW, Wah YW, Lian TT. Epidemiologic study of epilepsy in young Singaporean men. Epilepsia 1999;40:1384-7. doi:10.1111/j.1528-1157.1999.tb02009.x PMID:10528933
Spain Guillena municipality 1981 40 18 Mixed, children Nieto Barrera M. Neuroepidemiology of epilepsy. An Esp Pediatr 1988;29:59-63. PMID:3250297
Sri Lanka 218 villages belonging to 12 Gramodaya Centres 1983 690 49 Mixed Senanayake N. Epilepsy control in a developing country-the challenge of tomorrow. Ceylon Med J 1987;32:181-99. PMID:3506450
United States of America Copiah County 1978 246 40 Rural Haerer AF, Anderson D, Schoenberg B. Prevalence and clinical features of epilepsy in a biracial United States population. Epilepsia 1986;27:66-75. doi:10.1111/j.1528-1157.1986.tb03503.x PMID:3948820
United States of America US population 2004 123 50 Mixed Kobau R, Gilliam F, Thurman DJ. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004. Health Styles Survey Epilepsia 2006;47:1915-21. doi:10.1111/j.1528-1167.2006.00612.x
United States of America South Carolina 2003–5 379 50 Mixed Prevalence of epilepsy and health-related quality of life and disability among adults with epilepsy – South Carolina, 2003 and 2004. MMWR Morb Mortal Wkly Rep 2005;54:1080-2. PMID:16251865Ferguson PL, Chiprich J, Smith G, Dong B, Wannamaker BB, Kobau R, et al. Prevalence of self-reported epilepsy, health care access, and health behaviours among adults in South Carolina. Epilepsy Behav 2008;13:529-34. doi:10.1016/j.yebeh.2008.05.005 PMID:18585962


a Prevalence year not reported in manuscript, therefore publication year substituted.

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