Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa
Mark Hatherill, Monique Hanslo, Tony Hawkridge, Francesca Little, Lesley Workman, Hassan Mahomed, Michele Tameris, Sizulu Moyo, Hennie Geldenhuys, Willem Hanekom, Lawrence Geiter & Gregory Hussey
Volume 88, Number 4, April 2010, 312-320
Table 3. Differences in case frequencya yielded by nine structured approaches for the diagnosis of tuberculosis, South Africa, 2001–2006
| System | MASA | Migliori | SATVI | Osborne | Stoltz–Donald | Kibel | Fourie | WHO–Harries | Stegen–Toledo | No. (%) diagnosed with tuberculosis |
|---|---|---|---|---|---|---|---|---|---|---|
| MASA | 34.8 (32.3–37.3) | 44.2 (41.7–47.0) | 82.3 (80.3–84.3) | 22.0 (19.8–24.2) | 63.1 (60.5–65.7) | 23.5 (21.0–26.2) | 3.1 (1.3–5.1) | 46.5 (43.9–49.2) | 99 (6.9) | |
| Migliori | P < 0.0001 | 9.4 (6.7–12.2) | 47.5 (44.8–50.3) | 12.8 (10.0–15.6) | 28.3 (25.4–31.2) | 11.3 (8.3–14.1) | 31.7 (28.9–34.3) | 11.7 (9.8–13.7) | 602 (41.7) | |
| SATVI | P < 0.0001 | P < 0.0001 | 38.1 (35.3–40.8) | 22.2 (20.1–24.5) | 18.9 (16.0–21.7) | 20.7 (17.5–23.9) | 41.1 (38.3–43.9) | 2.3 (−0.3–4.9) | 739 (51.1) | |
| Osborne | P < 0.0001 | P < 0.0001 | P < 0.0001 | 60.3 (57.7–63.0) | 19.2 (16.9–21.6) | 58.8 (56.0–61.5) | 79.2 (76.9–81.4) | 35.8 (33.1–38.4) | 1289 (89.2) | |
| Stoltz–Donald | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | 41.1 (38.2–44.0) | 1.5 (−1.6–4.8) | 18.9 (16.1–21.6) | 24.5 (22.0–27.2) | 417 (28.9) | |
| Kibel | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | 39.6 (36.5–42.5) | 60.0 (57.3–62.6) | 16.6 (13.8–19.3) | 1011 (70.0) | |
| Fourie | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P = 0.344 | P < 0.0001 | 20.4 (17.9–22.9) | 23.0 (19.8–26.1) | 440 (30.4) | |
| WHO–Harries | P = 0.0009 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | 43.4 (40.6–46.2) | 145 (10.0) | |
| Stegen–Toledo | P < 0.0001 | P < 0.0001 | P = 0.083 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | P < 0.0001 | 772 (53.4) | |
| No. (%) diagnosed with tuberculosis | 99 (6.9) | 602 (41.7) | 739 (51.1) | 1289 (89.2) | 417 (28.9) | 1011 (70.0) | 440 (30.4) | 145 (10.0) | 772 (53.4) | 1445 (100) |
MASA, Medical Association of South Africa; SATVI, South African Tuberculosis Vaccine Initiative; WHO, World Health Organization.
a Absolute differences in proportion (denominator =1445) and corresponding 95% CIs are above diagonal spaces; McNemar’s test P-values for differences in proportion are below diagonal spaces.