Blood typing devices
In vitro diagnostic testing for the determination of blood groups is the basis of any blood transfusion and has been performed for decades.
WHO has been involved in this area since 1950s and a number of International Reference Preparations were developed for the control of blood typing reagents.
After a review and update in 1998, the Expert Committee on Biological Standardization (ECBS) decided the replacement of anti-D, complete, anti-D, incomplete as well as anti-A and anti-B would be a priority.
The function of the Reference Preparations is intended to be the definition of the minimum potency of the respective blood typing reagents. They are established for use with tubes and should be suitable for both polyclonal and monoclonal reagents. However, they are not designed to determine specificity.
Reference preparations are established for:
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Anti-A blood typing serum, human, Lyophilized. 470 IU / ampoule. (WHO/BS/81.1309)
pdf, 6.57Mb -
Instructions for use
pdf, 44kb -
Anti-B blood-typing serum, human, Lyophilized. 860 IU / ampoule. (WHO/BS/81.1309)
pdf, 6.57Mb -
Instructions for use
pdf, 44kb -
Anti-C complete blood-typing serum, human, Lyophilized. 100 IU / ampoule. (WHO/BS/83.1424)
pdf, 1.25Mb -
Instructions for use
pdf, 455kb -
Anti-c incomplete blood-typing serum, human, Lyophilized. 64 IU / ampoule. (WHO/BS/71.1038)
pdf, 210kb -
Instructions for use
pdf, 110kb -
Anti-D (anti-Rh0) incomplete blood-typing serum, human, Lyophilized. 32 IU / ampoule. (WHO/BS/66.810)
pdf, 3.57Mb -
Anti-E complete blood-typing serum, human, Lyophilized. 100 IU / ampoule. (WHO/BS/83.1424)
pdf, 1.25Mb -
Instructions for use
pdf, 455kb
In press
- Anti-D (anti-Rh0) complete blood-typing serum, mouse monoclonal. 1st International Standard for Minimum Potency of Anti-D Blood Grouping Reagents, Lyophilized. (WHO/BS/04.2000 Rev.1)
Replacement preparations will soon be available for:
- Anti-A and Anti-B complete blood-typing serum (report to ECBS 2004)
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OTHER WHO INTERNATIONAL REFERENCE MATERIALS
The characteristics of all reference preparations as well as the information regarding establishment can be found in the WHO Reference Material section.
Related documents
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Review and Update of the WHO International Standards for Blood Grouping Reagents. Amsterdam, The Netherlands (Oct 1999)
pdf, 56kb -
WHO Expert Committee on Biological Standardization (ECBS 1998), Technical Report Series (TRS) No 897, 49th report, p. 17. Geneva, Switzerland (2000), 49th report
pdf, 4.83Mb